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風濕免疫性疾病發病機制的相關研究

作者: 時間: 2013-08-23來源: 點擊:

muqianfengshixingjibingshangquefayouxiaodegenzhifangfa,qiyuanyinzaiyudaduoshufengshibingqueqiedebingyinjifabingjizhiqijinrengbumingque,yinerzaifengshixingjibingzhongkaizhanyimingqueqibingyinjifabingjizhiweimudejichuyanjiurengshibenxuekedefazhanfangxianghezhongdian。womennijiehebenzhoufengshibingtediankaizhanfengshibingyanjiu。zhuyaoxuanzeyixiajigefangxiang:

(1)guguanjieyandefabingjizhiyanjiu: guxingguanjieyan(oa)shicongguanjieruanguqibing,yingxiangzhenggeguanjiejiegou,baokuoruanguxiagu、rendai、huamo、guanjienangjiguanjiewaijirou,zuizhongyinguanjieruanguquanbutuoshierdaozhiguanjiejixinghegongnengsangshideyizhongjibing。guxingguanjieyanshishijieshangzuichangjiandeguanjiebing,suinianlingzengda,huanbinglvxunsushangsheng。guxingguanjieyanshilaonianrenguanjietengtonghezhicandezhuyaoyuanyin。jushijieweishengzuzhi(who)tongji,guxingguanjieyanzainvxinghuanbinglvzhongzhandisiwei,zainanxinghuanbinglvzhongzhandibawei,woguo60suiyishangzhexiguguanjieyanfabinglvgaoda49%。gaijibingsuodaozhidetengtong、guanjiegongnengzhangai,yanzhongjiangdilezhonglaonianrendeshenghuozhiliang,qiezengjialehuanzhedeyiliaofeiyong,yinerbeishouzhongshi。

guguanjieyan(oa)yuquhuayinzijiqishoutidexiangguanxingyanjiushiwomenshiyanshiyanjiudezhuyaofangxiang。womennicaiyongmianyibingli、meilianmianyixifufa、liushixibaofenxijishujixiandaifenzishengwufangfaduikangruanguxibaozishenkangti、jizhijinshudanbaimei、quhuayinzi、butishouti、xibaodiaowang、xueguanyiyangzuzhidengzaioafabingguochengzhongdezuoyongjinxingdeyanjiu。yiqimingquezhexiequhuayinzijiqishoutizaioafabingjizhizhongdezuoyong,weiyanfaxindezhiliaooadeyaowutigonglilunyiju。

(2)xitongxinghongbanlangchuangdefabingjizhiyanjiu: xitongxinghongbanlangchuang(systemic lupus erythematosus,sle)shiyizhongmimanxing、quanshenxingzishenmianyibing,zhuyaoleijipifuzhanmo、gugejirou、shenzangjizhongshushenjingxitong,tongshihuankeyileijifei、xinzang、xueyedengduogeqiguanhexitong,biaoxianchuduozhonglinchuangbiaoxian;xueqingzhongkejiancedaoduozhongzishenkangtihemianyixueyichang。slehaofayuqingniannvxing,fabinggaofengwei15-40sui,nannvfabingbiliwei1: 9zuoyou。younianhelaonianxingsledenannvzhibiyuewei1: 2。quanqiudehuanbinglvyuewei30-50/10wanren,woguodehuanbinglvyuewei70/10wanren。

zaiqianqiyanjiuzhongwomentongguoduojumeilianfanyingjianceleslehuanzhehla-g 14bpcharu/queshiduotaixingjiyinfenbu,tongshifenxilehla-gjiyinduotaixingduiwoguohanzusleyiganxingdeyingxiang。yanjiufaxian,guangguomin、pizhen、guanjieyanshenzangshoulei、xueyexitongjicnsshouleidengdefashenglvzaibutonghla-g14bpcharu/queshijiyinxinghuanzhezhijianwuxianzhuxingchayi;danquefaxiankanghistonekangtiyangxinglvzai-14/-14bpjiyinxinghuanzhemingxiangaoyu+14/+14bphe+14/-14bpjiyinxinghuanzhe,erjinyibufenxifaxianzhuyaowei+14/-14bpjiyinxingzhongde14bpcharudengweijiyinyukangrnpkangtichanshengyouguan。zaicijichushangwomenjiangjinyibuyanjiuhla-g 14bpjiyinduotaixingshizenyangtongguoyingxiangzishenkangtishengcheng,congercanyuslefabingjizhide。sledeyichuanyiganxingyanjiujiangchengweiwomenyanjiuslefabingjizhidezhongyaofangxiang。

(3)qiangzhixingjizhuyandefabingjizhiyanjiu: qiangzhixingjizhuyan(ankylosing spondylitis,as)shiyizhongzhouguanjiemanxingyanzhengweizhu,keleijineizangjiqitazuzhidemanxingjinzhanxingfengshixingjibing。ashaofayuqingniannanxing,zaoqizhengzhuangchangweiyaodibubushibingbanyouchenjiang,yekebiaoxianweijiaotixingtunqutong、fugugouqubushideng。suibingqingjinzhanzhujianxiangshangfazhanzhiyaozhui、xiongzhui、jingzhui,yinqijizhujixing、huodongshouxian。asqibingyinni,zaoqizhenduankunnan,shiwoguozhongqingniannanxingzhicandezhuyaojibingzhiyi。

qiangzhixingjizhuyanth1/th2xibaoyinzideyanjiushibenshiyanshidezhuyaoyanjiufangxiangzhiyi。nicaiyongmeilianmianyixifufacedingashuanzhewaizhouxuedangehexibaozhongifn-γ、il-2、il-4dengxibaoyinzidebiaoda,yijijianceguanjieyezhongth1/th2xingxibaoyinzizhongliuhuaisiyinzi-α(tnf-α)hebaixibaojiesu(il)-10deng;caiyongliushixibaofenxifafenbiejiancewaizhouxuelinbaxibaobiaomiancd3、cd4、cd8dengyinzi,qibaozhineixibaoyinzidebiaoda,th1、th2jitc1、tc2dengxibaodezuchengbilv。yanjiufenxiashuanzhethl/th2leixibaoyinzipudebianhua,yimingqueshangshuxibaoyinzizaiasfabingjizhizhongdezuoyong。

lingwai,jieheenshizhoujiqizhoubiandiquduojiandefengshimianyijibing,womenhuanjiangxuanzeleifengshiguanjieyan、tongfeng、xitongxingyinghuazhengdengjibingweiyanjiuduixiang,tebieshisschetongfengdefabingjizhiyanjiu,zhengqunengyouxindefaxianyutupo。

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